??????????? ??????

????????·???

???λ??: 江西快三实时开奖 > ???????? > ??????? >
????????????

????????/???????

????????????

??????????1.3-1.7???????????????????HCV?????????????????????????????????????????????????????????????????????????HCV???????????????????????????????????????????????????????????????Τ???PEG/RBV??????????????1???4???????У?PEG/RBV??????????????????50%?????????????????????????????80%??

2013???????Τ??Sovaldi????2014???????Harvoni????????????????????????????????DAA??????????HCV??????£???????????С??????????PEG/RBV?????????SVR??????100%????????????????????????????????????????????????е???????????FDA???????????????μ????Ч??DAA????????????????????????????????????????????????????????????У?????о???2???3?????顣??Щ???????????????е??????????????????????????????????????????????÷??棬?????????????????????????????????????е?????????

???????й?????λ?????????1000-3000???????DAA????????????Τ??????Τ???????????й????У?????????????????500λ????????????????????Щ??Ч?????????Ч????????????????????????Щ????????????????????????????????й???????DAA????????????о???????????????????????????о??????clinicaltrials.gov??????????????????????????????????????????й????????DAA????????Ч????????????????????????????о????????????????л?????????????????????????????????????μ???????????????о?????????й????λ???????????????????????????

??????е????

1. ???????л????????о?????

2. ????????????????????

??????绰??17199912074[email protected]
????????????

?????馽?????????????????????????й????????????????о?????й????????????????о?????????????????????????????????????????????Ч??????????????????????????????????????????????????е??????????????????????????????????????λ????????????????????????????????????????????????????????????????????????????????????????????????????????????????

?????????????????????????????塱???????塱???????????????????????????ο????????????????????????????о?(clinnicaltrials.gov ????: NCT01434212 and NCT01760148)?????з???????о????飬????????е??????

?????????????????????????????????????????????????????о????????Ч????????о????? ????п?????????????????????????????????????????ο??????????????? ?й??????????????о???

??????????????

  • 1Hu Y, Mao K, Zeng Y, Chen S, Tao Z, Yang C, Sun S, et al. Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production. J Immunol 2010;185:7699-7705.
  • 2Wang Y, Yang C, Mao K, Chen S, Meng G, Sun B. Cellular localization of NLRP3 inflammasome. Protein Cell 2013;4:425-431.
  • 3Shi X, Chi X, Pan Y, Gao Y, Li W, Yang C, Zhong J, et al. IL28B is associated with outcomes of chronic HBV infection. Yonsei Med J 2015;56:625-633.
  • 4Yang C, Zhao X, Sun D, Yang L, Chong C, Pan Y, Chi X, et al. Interferon alpha (IFNalpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. Cell Mol Immunol 2016;13:94-102.
  • 5Dachuan Li, Qing Li, Nong Cheng, Jingyan Song. ??Sampling-based real-time motion planning under state uncertainty for autonomous micro aerial vehicles in GPS-denied environments??. Sensors, 2014, 14(11): pp21791-218256.
  • 6Dachuan Li, Qing Li, Liangwen Tang, Sheng Yang, Nong Cheng, Jingyan Song. "Invariant Observer-Based State Estimation for Micro-Aerial Vehicles in GPS-Denied Indoor Environments Using an RGB-D Camera and MEMS Inertial Sensors". Micromachines, 2015, 6(4): pp 487-522
  • 7Qing Li, Dachuan Li, Qinfan Wu, Liangwen Tang, Yan Huo, Yixuan Zhang, Nong Cheng. ??Autonomous navigation and environment modeling for MAVs in 3-D enclosed industrial environments,?? Computer in Industry, vol.64, no.9: pp 1161-1177, 2013
  • 8Dachuan Li, Qing Li, Nong Cheng, Jingyan Song, ??Extended RRT-based path planning for flying robots in complex 3D environments with narrow passages,?? in IEEE International Conference on Automation Science and Engineering (CASE), 2012.
  • 9Dachuan Li, Qing Li, Nong Cheng, Qinfan Wu, Jingyan Song, Liangwen Tang, ??Combined RGBD-inertial based state estimation for MAV in GPS-denied indoor environments,?? in 9th Asian Control Conference, 2013.
  • 10Dachuan Li, Qing Li, Nong Cheng, Qinfan Wu, Jingyan Song, Liangwen Tang, ??Invariant observer design of a RGB-D aided inertial system for micro aerial vehicles in GPS-denied environments??, in IEEE International Conference on Systems, Man and Cybernetics (SMC), 2013.
?????????????????

Abstract: About 130-170 million people, is estimated to be infected with the hepatitis C virus (HCV). Chronic HCV infection is one of the leading causes of liver- related death and in many countries it is the primaryreason for having a liver transplant. The main aim of antiviral treatment is to eradicate the virus. Until a few years ago the only treatment strategy was based on the combination of pegylated interferon and ribavirin (PEG/RBV). However, in genotypes 1 and 4 the rates of viral response did not surpass 50%, reaching up to 80% in the rest. In 2013 and 2014 approval were given for the direct acting antiviral agents (DAA), sovaldi and harvoni, serially, for treatment of HCV patients. These DAA created a new scenario: shorter therapies, less toxicity (free of PEG/RBV), increased rates of SVR (even up to 100%), with pan-genomic properties and excellent tolerance.This has enabled their almost generalised applicability in all patients. Recent years, FDA approved a series of new more effective DAA, However, it should be noted that most of the scientific evidence available is based on expert opinion, case-control series, cohort studies and phase 2 and 3 trials, some with a reduced number of patients and select groups. Few data are currently available about the use of these drugs in daily clinical practice, particularly in relation to the appearance of side effects and interactions with other drugs, or their use in special populations or persons with the less common genotypes. This situation suggests the need for the generalised implementation of registries of patients receiving antiviral therapy. In a clinical study carried out in china, 500 HCV patients received recent DAA treatment. The results indicate that...

Key words: Hepatitis C; Treatment; Direct acting antiviral agents; Chinese Patients; Outcome

??????绰??17199912074[email protected]
????????????
------?????----------------------------
????????
???????
??????
???????
???????
??????
??????
????????
y?屨??
???????
???????
?????
????????
???????
????????????

???

???

???????
???????????

???

???????绰??4006 120 152

  • 还是中国足球队最牛,因为他稳定;中国股市就不一样了,怎么形容呢?唉,还不如中国足球! 2018-12-07
  • 四川达州塔沱市场火灾扑灭消防官兵撤离 相关责任人被刑拘 2018-12-06
  • 广东:取餐“太用力” 外卖小伙撞破玻璃门 2018-12-04
  • 赞扬和推荐看着就想笑文章《如何制订企业发展计划》 2018-12-04
  • 重庆私藏的绝美古镇 悠闲不打挤 2018-11-26
  • 风水神的偷梁换柱,能骗的了人么 2018-11-09
  • 确认过剧集,陈坤和万茜是来搞笑的! 2018-11-03
  • 泗城镇:建设四好农村路 续写民生新篇章 2018-11-03
  • 这个错误的观点在自以为懂得马克思主义的人群中很普遍,非常普遍! 2018-11-02
  • [微笑]你说的这种情况越来越少了,一是人们的素质都在不断提高,二是有相应的管理机制。 2018-11-02
  • 人民日报评论员:牢牢把握新时代中国共产党的历史使命 2018-10-03
  • 鼓励更多社会主体投身创新创业 2018-07-14
  • [雷人]没意思!拔剑四顾无敌手!不玩了,左左右右慢慢啃…… 2018-07-14
  • 村教扶智,幕天在行动:“千城万区助村教”行动走进北京、泉州等全国各地城市 2018-07-13
  • 习近平:坚持绿色低碳,建设一个清洁美丽的世界 2018-07-13
  • 468| 146| 805| 534| 52| 963| 905| 828| 288| 55|